NMNMASTER

100% purity

The raw material is NMN at 100% purity. NMN is converted in the body into the coenzyme NAD, which is involved in how cells produce energy and repair themselves, and whose levels have been reported to fall with age.

Made at a GMP-certified plant in Japan

Manufacturing takes place at a Japanese plant certified to GMP (Good Manufacturing Practice). Every stage, from goods-in to despatch, is managed against a defined quality standard.

Infusion or supplement

The NMN infusion is an intensive approach delivered directly into the bloodstream; NMNMASTER is one that is easy to keep up day to day. A doctor will recommend one according to your goal and your lifestyle, and some patients use both.

More about NMN Infusion

How it differs from an ordinary supplement

Supplements sold over the counter are sometimes designed around price and volume. A product supplied through a clinic tends to have a clearer rationale behind its formulation, because the doctor involved in designing it also sees patients and their conditions.

That said, the phrase "doctor's supplement" has no legal definition. Anyone may use it. What actually differs has to be checked on three separate counts: the raw material, the manufacturing, and the formulation.

"Doctor-supervised" is not the same as "formulated by a doctor"

"Doctor-supervised", which appears often in advertising, can mean no more than that a doctor looked at the finished product. "Formulated by a doctor" means involvement from the point of deciding which ingredients go in, and how much of each.

Which phrase a product uses tells you how deep that involvement went.

From NMN to NAD

NMN taken as a supplement does not act as it is. It only plays a part once the body has converted it into NAD, and other nutrients have been reported to be involved in that conversion.

So the relationship is not a simple one in which more NMN means proportionally more NAD. That is why formulation matters in how a supplement is designed.

What is not yet known

The role of NAD and its decline with age have been reported on. The long-term effects of taking NMN in humans are still under study, and a number of points remain unsettled.

A supplement is a food, and we cannot make claims about its effects. Products that use categorical language — "guaranteed to make you younger" — warrant caution.

What separates 100% purity from 99%

Purity is a measure of how free the NMN powder used as raw material is of anything else. 100% purity means that material consists of NMN and nothing else.

It is worth being clear that this is the purity of the raw material, not a claim that the product as a whole is only NMN. Capsules contain other ingredients as well. Purity tells you about the quality of the material going in.

Where no purity figure is published, there is nothing on which to judge the quality of the material.

Read the amount per day, not per box

Amounts are sometimes stated per box, but what matters for comparison is the amount per day. A large total in the box means little if the daily dose is small.

The intakes used in research are generally in the range of 250 to 500 mg a day. Using that as a reference and setting the daily amount against the price is what makes the differences between products visible.

Is every ingredient disclosed?

Whether all ingredients are listed is the basic measure of how open a maker is. Where the headline ingredient is printed large and the rest left vague, there is no way to check what is in the product.

This matters most for products that advertise a combined formulation: without knowing what is in it and how much, the thinking behind the design cannot be read.

What a GMP-certified plant is

GMP (Good Manufacturing Practice) is a standard for managing quality at every stage, from goods-in through manufacturing to despatch.

Because supplements are classified as foods, no manufacturing standard is imposed on them by law, as it is on pharmaceuticals. That is precisely why GMP certification is one of the few things on which manufacturing can be judged.

A GMP-certified plant in Japan meets standards set out in guidelines from the Ministry of Health, Labour and Welfare.

NMN alone, or a combination

NMN is converted into NAD in the body, and other nutrients have been reported to take part in that conversion. A product that simply packs in a large quantity of NMN reflects a different line of thinking from one that combines ingredients supporting the conversion.

Which is better depends on your purpose, but whether it is a single ingredient or a combination is something to check every time. Where a combination is advertised, it is also worth seeing whether the reason for each ingredient is explained.

Who designed the formulation

Whether the product says who decided the formulation tells you something about its character. Where a doctor or specialist was involved, check whether it also says from what stage.

As above, "supervised" and "formulated" describe very different depths of involvement.

None of the three can be skipped

However pure the material, the finished product is not assured if the process is loosely controlled. However sound the manufacturing, it means little if there is no reasoning behind the formulation.

Price alone cannot settle it because the cost sits in a different one of these three layers from product to product. Within the same price bracket, one will have spent on the raw material and another on the number of ingredients.

Why a combination

Other nutrients have been reported to take part in the conversion of NMN into NAD. Rather than simply raising the quantity of NMN, we have taken the approach of combining ingredients that support that conversion.

As a clinic specialising in regenerative medicine, we also provide autologous stem cell therapy, exosome therapy and others. Because treatments and the supplement are handled at the same clinic, if you are considering using both, the same doctor can advise you with your full picture in view.

Using both

Some patients combine the infusion with the supplement. There is no need to settle on one or the other.

Bring your goal and how easily you can get to the clinic to your consultation, and discuss it with your doctor.

1. The amount falls short

Some products deliver a daily intake well below the amounts used in research, generally put at 250 to 500 mg a day. Choosing on the per-box figure alone hides what you actually take each day.

2. It has not been taken for long enough

A supplement is a food, and not something that shows a change over a short period. One to three months of continued use is the usual reference point. Judgements are often made after days or weeks.

3. Material and manufacturing quality vary

Where no purity figure is published, or no manufacturing standard is stated, there is no way to confirm that the product contains what its label says.