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Stem Cell Supernatant
Stem Cell Culture Supernatant
Last updated: 10 July 2026
Stem cell culture supernatant is a treatment that uses the fluid drawn off during stem cell culture, which is rich in growth factors and cytokines. What distinguishes it is that no cells are administered — only what the cells secreted. The profile of those components differs according to the source tissue: adipose, umbilical cord or dental pulp. We offer it by IV drip and by injection.
About
About this treatment
What culture supernatant is
As stem cells are cultured, they secrete a range of growth factors and cytokines — the signalling molecules cells use to communicate — into the culture medium. The fluid collected from above that culture is the supernatant. Because no cells themselves are administered, it sits in a different category from cell therapy.
Differences by source tissue
We work with supernatant from three source tissues: adipose, umbilical cord and dental pulp. The balance of components is reported to differ by source, and a doctor will recommend one according to what you are aiming for.
Flow
What happens, step by step
Consultation and examination
The doctor checks your condition and what you are hoping for, and explains the treatment, the cost, the safety data and the matters relating to unapproved drugs in full.
Choosing source and route
We recommend a source tissue (adipose, umbilical cord or dental pulp) and a route (IV drip or injection) according to what you are aiming for.
Administration
Given by IV drip or by injection.
Follow-up
We check for any change in how you feel after administration.
For You
Who this may suit
- People aiming at whole-body age care, recovery from fatigue and better sleep
- People whose interest is vascular ageing, with arterial health in mind
- People who want to work on immune balance
- People concerned about acne scarring and redness, by way of an anti-inflammatory approach
- People concerned about pigmentation and dullness, by way of normalising cell turnover
Whether this treatment is suitable for you is decided by a doctor at your consultation.
Outline
At a glance
- Method
- IV drip or injection
- Source tissue
- Adipose | umbilical cord | dental pulp
- Cost
- Culture supernatant / exosome IV drip (umbilical cord, dental pulp, adipose, exosome)from ¥88,000
The price depends on the preparation. The price for injections is given at your consultation.
Prices match our official menu (as of September 2026). The full cost is confirmed at your consultation.
Certification
Registration and hospital partnerships
Under Japan's Act on the Safety of Regenerative Medicine, our Class 2 protocols are reviewed by a Certified Special Committee for Regenerative Medicine and our Class 3 protocols by a Certified Committee for Regenerative Medicine. The resulting treatment plans are filed with the Kanto-Shinetsu Regional Bureau of Health and Welfare. We also work in partnership with Keio University Hospital and Tokyo Saiseikai Central Hospital, covering pre- and post-treatment testing and, should it ever be needed, transfer of care.
Safety
How we manage safety
Every medical treatment, regenerative medicine included, carries some risk and some precautions. We go through each of them with you at the consultation beforehand, and proceed only once you are satisfied.
Treatment may cause side effects or changes in how you feel. Results and recovery vary from person to person, and no particular outcome is guaranteed. If you notice anything that concerns you, please contact us promptly.
FAQ
Frequently asked questions
QHow does this differ from stem cell therapy?＋
Stem cell therapy administers the cells themselves. Culture supernatant uses only what the cells secreted — growth factors, cytokines and so on. The fact that no cells are administered is the main difference.
QWhich source tissue should I choose?＋
Which one suits you depends on your goal and your condition. A doctor will recommend one after examining you.
QIs it an approved drug?＋
Culture supernatant is not approved as a pharmaceutical in Japan. We provide it as private treatment, and a doctor explains the matters relating to unapproved drugs at your consultation.
QIs this covered by insurance?＋
This is private treatment and is not covered by Japanese public health insurance. The full cost is presented to you at your consultation.
Notice
Important information
- This treatment is private and is not covered by Japanese public health insurance.
- Results and recovery vary from person to person. This page is general information and does not guarantee any particular outcome.
- Stem cell culture supernatant is an unapproved pharmaceutical product in Japan. It has not been approved under the Pharmaceuticals and Medical Devices Act. At your consultation a doctor will explain how it is sourced, whether an approved equivalent exists in Japan, and the available safety information from other countries.
- Suitability, safety, side effects and cost are explained in detail by a doctor at your consultation.
Consultation
Your first consultation
At your first visit a doctor will examine you and explain the treatment, the cost and the safety data in full. Please feel free to get in touch.
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